Really, go read the issue first if you don't want spoilers.
Next, Happy Pi Day! :D
The title pretty much describes what's going on with Nasty. She's confused, she's not where she thought she should be. And, yes, Subject 4 is working on altering her memories, as the Coordinator tells the two people who brought Nasty in. Eleven's concerns should make sense once Issue 11 is posted tomorrow.
Meanwhile, Maria is still showing that she's not that great a parent. She had a kid far too young, lost her "sowing wild oats" years and, once Nasty could take care of herself, tried to make up for it. Her plotline will continue. Why should Nasty be the only one forced to have character development?
Back in Nasty's head, she's making it difficult for Subject 4 to lay new memory tracks. Think of all the details you have in your life. Now consider how many of them are summed up with a word or two - "home", "the computer", "work", "the guys". Expand those words, though. Is "home" just an address? Or does "home" encompass not just a layout of your home but the feeling you have when you return from work or school? Do you even keep a layout of "home" in mind? How much of "home" do you take for granted? This is what Subject 4 is facing with Nasty. Nasty's beloved "bike" is, as described way back in Issue 1 as "an aging Kawasaki in desperate need of new paint". Subject 4 managed to make a saving throw and adjust the "car" for the situation, but it was a close one. Yes, telepathy can be fought, even without needing an earworm.
Tomorrow, Nasty's training continues.
Saturday, over at Fan To Pro, my review of The Incredible Hulk will be up.
Still to come, some NaNoWriMo prep work.